N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosinehydrochloride

Name	GW1929
Synonyms	GW1929 GW1929 HYDRATE GW 1929 hydrochloride N-(2-BENZOYLPHENYL)-O-[2-(METHYL-2-PYRIDINYLAMINO)ETHYL]-L-TYROSINE N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrate N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosinehydrochloride (2S)-2-(2-benzoylanilino)-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]propanoic acid (S)-2-(2-Benzoylphenylamino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoic acid
CAS	196808-24-9
InChIKey	QTQMRBZOBKYXCG-MHZLTWQESA-N

Molecular Formula	C30H29N3O4
Molar Mass	495.57
Density	1.264±0.06 g/cm3(Predicted)
Boling Point	749.2±60.0 °C(Predicted)
Solubility	DMSO: 20mg/mL
Appearance	solid
Color	yellow
pKa	3.91±0.10(Predicted)
Storage Condition	Desiccate at +4°C
In vitro study	GW1929 is a potent PPAR-γ activator, with pK i s of 8.84, < 5.5, and < 6.5 for human PPAR-γ, PPAR-α, and PPAR-δ, and pEC 50 s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively. GW1929 (10 μM) inhibits TBBPA-induced caspase-3 increase and TBBPA-stimulated LDH release in neocortical cell cultures.
In vivo study	GW1929 (0.5, 1, 5 mg/kg, p.o.) highly decreases nonfasted plasma glucose levels in Zucker diabetic fatty (ZDF) rats after treatment for 14 days, and possesses antilipolytic efficacy. GW1929 (1, 5 mg/kg, p.o.) increases glucose-stimulated insuline secretion of β-cell in ZDF rats.

WGK Germany

Last Update：2024-01-02 23:10:35

biological activity	GW1929 is an effective PPAR-γ agonist, and the pKi of human PPAR-γ is 8.84. The pEC50 for human and mouse is 8.56 and 8.27 respectively.
target	PPAR-γ 8.56 (pEC 50 , Human PPAR-γ)
in vitro research	GW1929 is a potent PPAR-γ activator, with pK I s of 8.84, < 5.5, and < 6.5 for human PPAR-γ, PPAR-α, and PPAR-δ, and pEC 50 s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively. GW1929 (10 μM) inhibits TBBPA-induced caspase-3 increase and TBBPA-stimulated LDH release in neocortical cell cultures.
in vivo study	GW1929 (0.5, 1, 5 mg/kg, p.o.) high decreases nonfasted plasma glucose levels in Zucker diabetic fatty (ZDF) rats after treatment for 14 days, and possesses antilipolytic efficacy. GW1929 (1, 5 mg/kg, P. o.) increases glucose-stimulated insuline secretion of β-cell in ZDF rats.

Last Update：2024-04-09 21:54:55

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Product Name: GW1929 Visit Supplier Webpage Request for quotation
CAS: 196808-24-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosinehydrochloride Request for Quotation